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However, the specific modulatory effect of sex hormones on pain among men and women requires further exploration. Psychosocial processes such as pain coping and early-life exposure to stress may also explain sex differences Cock women sex pain, in addition to stereotypical gender roles that may contribute to differences in pain expression.

Therefore, this review will provide a brief overview of the extant literature examining sex-related differences in clinical and experimental pain, and highlights several biopsychosocial mechanisms implicated in these male—female differences. The future directions of this field of research are discussed with an emphasis aimed towards further elucidation of mechanisms which may inform future efforts to develop sex-specific treatments.

Keywords: gender differences, opioid analgesics, pain, pain perception, sex differences Editor's key points There is increasing evidence for sex differences in pain sensitivity and analgesic response.

Clinical pain, both acute and chronic, and experimental pain models all show sex differences. While chronic pain is commoner in women the evidence on pain severity is less clear.

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Research Missed opportunity at Steins Bar sex, gender, and pain has proliferated in recent decades. Recent publications provide thorough examinations of various areas of this literature, 1 — 8 Hory women Carey Idaho in this brief review article we intend to highlight and summarize important findings regarding sex, gender, and pain.

Specifically, we will discuss findings regarding sex differences in clinical pain prevalence and severity, followed by a brief review of sex differences in experimental measures of pain perception.